In:
Kidney and Blood Pressure Research, S. Karger AG, Vol. 25, No. 4 ( 2002), p. 245-249
Abstract:
〈 i 〉 Background: 〈 /i 〉 Despite new immunosuppressive drugs, only a minority of graft survive over 15 years. The aim of our study was to determine the influence of gene polymorphisms in the G-protein-β 〈 sub 〉 3 〈 /sub 〉 subunit (Gβ3) and endothelial nitric oxide synthase (eNOS) on the long-term outcome of kidney grafts. 〈 i 〉 Methods: 〈 /i 〉 Using PCR, corresponding genotypes in Gβ3 (C825T) and eNOS (G894T) gene polymorphism were evaluated in patients with preserved graft function over 15 years and in a control group of transplant recipients. 〈 i 〉 Results: 〈 /i 〉 There were no differences in allele and genotype distributions of both polymorphisms between groups. In Gβ3 polymorphism, the 825T allele carriers had a significantly lower body mass index while in eNOS polymorphism there were no links between genotypes, renal function and atherosclerosis risk factors. 〈 i 〉 Conclusions: 〈 /i 〉 Our data suggest that these gene polymorphisms have only a minor influence on long-term renal graft function.
Type of Medium:
Online Resource
ISSN:
1420-4096
,
1423-0143
Language:
English
Publisher:
S. Karger AG
Publication Date:
2002
detail.hit.zdb_id:
1482922-8