In:
Acta Haematologica, S. Karger AG, Vol. 110, No. 4 ( 2003), p. 179-183
Abstract:
〈 i 〉 Background: 〈 /i 〉 Methods to simplify the stem cell transplantation procedures are needed mainly in developing countries. We have previously shown that unprocessed leukapheresis material is useful to restore hematopoiesis after high-dose chemotherapy. 〈 i 〉 Methods: 〈 /i 〉 Over a 10-year period in a private practice setting, we prospectively performed autotransplants using noncryopreserved and unmanipulated peripheral blood stem cells mobilized from the bone marrow to the peripheral blood by means of filgrastim and using a single-day conditioning regimen with high dose (200 mg/m 〈 sup 〉 2 〈 /sup 〉 ) melphalan. 〈 i 〉 Results: 〈 /i 〉 Forty-six individuals were given 50 autografts. The median age of the patients was 33 years (range 8–69). Twenty-two patients with acute leukemia (13 with myeloblastic and 9 with lymphoblastic leukemia), 4 with chronic myelogenous leukemia, 6 with multiple myeloma, 7 with Hodgkin’s disease, 3 with non-Hodgkin’s lymphoma and 4 with metastatic breast carcinoma were included. The median time to achieve 〉 0.5 × 10 〈 sup 〉 9 〈 /sup 〉 /l granulocytes was 14 days (range 0–86), whereas the median time to achieve 〉 20 × 10 〈 sup 〉 9 〈 /sup 〉 /l platelets was 25 days (range 0–102). The 3,300-day posttransplant survival was 63%, the median posttransplant overall survival was over 3,300 days, the 3,300-day disease-free survival was 50% and the transplant-related mortality was 2%. The procedure was performed entirely on an outpatient basis in the case of 48 autografts (96%). The approximate cost of each graft was 7,500 USD. 〈 i 〉 Conclusion: 〈 /i 〉 This simplified method to autograft patients, avoiding in-hospital stays, purging procedures and cryopreservation of the cells, is feasible and results in a substantial decrease in the cost of the autologous hematopoietic stem cell transplantation methods.
Type of Medium:
Online Resource
ISSN:
0001-5792
,
1421-9662
Language:
English
Publisher:
S. Karger AG
Publication Date:
2003
detail.hit.zdb_id:
1481888-7
detail.hit.zdb_id:
80008-9
