In:
Neuropsychobiology, S. Karger AG, Vol. 49, No. 4 ( 2004), p. 185-188
Abstract:
Membrane phospholipid abnormalities have been proposed to be involved in the pathogenesis of mood disorders, and in signal transduction and neurotransmitter uptake. Cytosolic phospholipase A 〈 sub 〉 2 〈 /sub 〉 (cPLA 〈 sub 〉 2 〈 /sub 〉 ) is not only an essential enzyme in the metabolism of fatty acids but also in signaling process. Therefore, we examined the association between the 〈 i 〉 Ban 〈 /i 〉 I polymorphism of the cPLA 〈 sub 〉 2 〈 /sub 〉 gene and mood disorders. Sixty-two patients with major depressive disorder (MDD), 50 patients with bipolar I disorder (BID) and 117 healthy controls participated in this study. Genotyping was performed by using PCR-based methods. Genotype and allele distributions in MDD patients were significantly different from those of the controls. In particular, the A2 allele was associated with increased risk of MDD development (p = 0.007, odds ratio = 1.827; confidence interval = 1.141–2.927). However, the polymorphism was not different between BID patients and controls in genotype and allele distribution. This preliminary study indicates the need for further studies on the potential role of the cPLA 〈 sub 〉 2 〈 /sub 〉 gene polymorphism in the susceptibility to mood disorders.
Type of Medium:
Online Resource
ISSN:
0302-282X
,
1423-0224
Language:
English
Publisher:
S. Karger AG
Publication Date:
2004
detail.hit.zdb_id:
1483094-2
SSG:
5,2
SSG:
15,3