In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 135, No. 1 ( 2004), p. 73-82
Kurzfassung:
Anergy, tolerance and active suppression may not be independent events, but rather involve similar mechanisms and cell types in immune regulation. Induction of allergen-specific regulatory/suppressor T cells (T 〈 sub 〉 Reg 〈 /sub 〉 ) seems essential for the maintenance of a healthy immune response to allergens. Allergen-specific immunotherapy can induce specific T 〈 sub 〉 Reg 〈 /sub 〉 cells that abolish allergen-induced proliferation of T helper 1 (Th1) and Th2 cells, as well as their cytokine production. T 〈 sub 〉 Reg 〈 /sub 〉 cells utilize multiple suppressive mechanisms, interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) as secreted cytokines and CTLA-4, PD-1, mTGF-β, mIL-10, TGF-βR and IL-10R as surface molecules. An important aspect of T 〈 sub 〉 Reg 〈 /sub 〉 cells is the regulation of antibody isotypes and suppression of proinflammatory cells. IL-10 and TGF-β secreted by T 〈 sub 〉 Reg 〈 /sub 〉 cells skew production of IgE towards the noninflammatory isotypes, IgG4 and IgA, respectively. Furthermore, T 〈 sub 〉 Reg 〈 /sub 〉 cells may directly or indirectly suppress effector cells of allergic inflammation such as basophils and eosinophils. In conclusion, induction of antigen-specific T 〈 sub 〉 Reg 〈 /sub 〉 cells may redirect an inappropriate immune response against allergen or autoantigens with the help of a broad range of suppressor mechanisms.
Materialart:
Online-Ressource
ISSN:
1018-2438
,
1423-0097
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2004
ZDB Id:
1482722-0
