In:
Fetal Diagnosis and Therapy, S. Karger AG, Vol. 22, No. 3 ( 2007), p. 161-168
Kurzfassung:
〈 i 〉 Objectives: 〈 /i 〉 To assess the messenger ribonucleic acid expression in placental tissue of growth factors, cytokines, angiogenic and anti-angiogenic factors in one case of recurrent multiple chorioangiomas. 〈 i 〉 Methods: 〈 /i 〉 Complementary deoxyribonucleic acid array analysis was performed on the affected placentae and on normal placentaes (controls) to compare messenger ribonucleic acid levels of 96 genes involved in angiogenesis. 〈 i 〉 Results: 〈 /i 〉 Eleven genes presented more than two-fold alteration in expression levels: undetectable (angiopoietin 1, osteonectin, tyrosine kinase endothelial, neuropilin 1), decreased (transcription growth factor β receptor 3, tissue inhibitor of metalloproteinase type 2, EGF receptor, integrin-α V, tyrosine kinase vascular endothelial growth factor receptor 2), increased (angiopoietin 2, osteopontin). 〈 i 〉 Conclusions: 〈 /i 〉 We illustrated the complexity of angiogenic disruption in recurrent multiple chorioangiomas leading to the difficulty to propose a single candidate gene to explain this pathology.
Materialart:
Online-Ressource
ISSN:
1015-3837
,
1421-9964
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2007
ZDB Id:
1482292-1
