In:
Cerebrovascular Diseases, S. Karger AG, Vol. 25, No. 1-2 ( 2008), p. 50-58
Abstract:
〈 i 〉 Background: 〈 /i 〉 We have recently shown that ischemic stroke causes a stress-mediator-induced long-lasting immunodepressive state in mice. 〈 i 〉 Methods: 〈 /i 〉 Using head magnetic resonance imaging and standardized immunoassays, we prospectively investigated whether poststroke immunodepression is also seen in humans. 〈 i 〉 Results: 〈 /i 〉 Compared to healthy volunteers (n = 30), a rapid depression of lymphocyte counts and a functional deactivation of monocytes and T helper type 1 cells was observed in acute stroke patients (SP; n = 40). Immunodepression was more pronounced in patients with severe clinical deficit or large infarction. On admission the combination of monocytic tumor necrosis factor α release ex vivo and the National Institute of Health Stroke Scale score were the best predictors for nosocomial infection, preferentially affecting older SP. 〈 i 〉 Conclusion: 〈 /i 〉 Our data provide evidence for an immediate suppression of cell-mediated immune responses after ischemic stroke in humans.
Type of Medium:
Online Resource
ISSN:
1015-9770
,
1421-9786
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1482069-9