In:
Public Health Genomics, S. Karger AG, Vol. 11, No. 3 ( 2008), p. 150-159
Abstract:
〈 i 〉 Objective: 〈 /i 〉 The aim of the study was to investigate genetic heterogeneity among local Japanese populations. 〈 i 〉 Methods: 〈 /i 〉 We performed a single nucleotide polymorphism (SNP) study of four demographically distinct local populations (population 1: a large city; population 2: isolated islands; populations 3 and 4: rural areas). Seventy SNPs in a region spanning 5 Mb of chromosome 17 known to be a candidate region for essential hypertension were genotyped and linkage disequilibrium analyses were performed. 〈 i 〉 Results: 〈 /i 〉 Statistical analyses of SNP allele frequencies and haplotype distribution showed significant divergence among the populations, mostly between population 2 and the other populations. Pairwise D′ declined with increasing population size, and smaller populations retained a high linkage disequilibrium. 〈 i 〉 Conclusion: 〈 /i 〉 Population 2 is likely to have a different ancestry from the majority of the Japanese population, whereas the heterogeneity among the other populations may result from differences in population size or geographic background.
Type of Medium:
Online Resource
ISSN:
1662-4246
,
1662-8063
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
2457026-6