In:
Pediatric Neurosurgery, S. Karger AG, Vol. 44, No. 5 ( 2008), p. 382-387
Abstract:
〈 i 〉 Introduction: 〈 /i 〉 Central nervous system tumours represent 20% of all childhood cancers, and are the second most common group of neoplasms after leukaemias. 〈 i 〉 Objective: 〈 /i 〉 To describe epidemiological characteristics of central nervous system tumours in a paediatric Tunisian population. 〈 i 〉 Patients and Methods: 〈 /i 〉 A retrospective study of 492 childhood central nervous system tumours operated between 1990 and 2004 was undertaken. We investigated the age-related location, gender distribution and the histology of all tumours, and adopted the latest WHO classification (2007) in grouping all the tumours. 〈 i 〉 Results: 〈 /i 〉 There were 488 primary and 4 secondary tumours; 426 (86.6%) were intracranial and 66 (13.4%) were intraspinal. Of the 426 intracranial tumours, 214 (50.24%) were supratentorial and 212 (49.76%) were infratentorial. The median age at diagnosis was 8 years, with a male:female ratio of 1.14:1. Low-grade tumours (WHO I/II) constituted 67.3% of all lesions and the rest (32.7%) were high-grade tumours (WHO III/IV). The most common tumour found in our series was astrocytoma (38%), followed by medulloblastoma (16.2%), then ependymoma (6.9%), cystic tumours (6.3%) and craniopharyngioma (5.3%). The overall 5-year survival rate was 45% with a mean follow-up period of 36 months. 〈 i 〉 Conclusion: 〈 /i 〉 In our patient population, the incidence and distribution of central nervous system tumours were similar to those reported in literature. Overall survival rates varied according to tumour location and histopathology.
Type of Medium:
Online Resource
ISSN:
1016-2291
,
1423-0305
Language:
English
Publisher:
S. Karger AG
Publication Date:
2008
detail.hit.zdb_id:
1483546-0
