In:
Urologia Internationalis, S. Karger AG, Vol. 82, No. 1 ( 2009), p. 43-47
Abstract:
〈 i 〉 Objectives: 〈 /i 〉 To investigate the alterations of urine transforming growth factor-β1 (TGF-β1) and basic fibroblast growth factor (bFGF) following bladder outlet obstruction (BOO) in rats and to determine their correlation with the impaired detrusor contractibility. 〈 i 〉 Methods: 〈 /i 〉 Wistar rats were divided into control, 2-week BOO 6-week and BOO groups. Impaired detrusor contractibility was quantified by measuring detrusor contraction force (DCF) of detrusor strip stimulated by carbachol. The enzyme-linked immunosorbent assay method was used to determine the urine levels of the 2 factors. Correlation analysis was conducted between DCF and urine levels of the 2 factors to see if there was an association between them after BOO. 〈 i 〉 Results: 〈 /i 〉 DCF was found to be significantly lower in the 6-week BOO group than in the 2-week BOO and control groups. There is no significant difference regarding urine TGF-β1 between the 2-week BOO and control groups (p 〉 0.05). Urine TGF-β1 level in the 6-week BOO group was significantly higher than in the 2-week BOO (p 〈 0.05) and control groups (p 〈 0.05). There existed a negative correlation between DCF and urine TGF-β1 (p 〈 0.05). 〈 i 〉 Conclusions: 〈 /i 〉 In an animal model, our results have suggested the potential role of urine TGF-β1 as a noninvasive biomarker to predict detrusor contractibility after BOO.
Type of Medium:
Online Resource
ISSN:
0042-1138
,
1423-0399
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1464417-4
