In:
Medical Principles and Practice, S. Karger AG, Vol. 18, No. 2 ( 2009), p. 137-142
Abstract:
〈 i 〉 Objective: 〈 /i 〉 To investigate the possible association between 〈 i 〉 factor XII (F12) 〈 /i 〉 gene variant and the presence of coronary artery disease (CAD) in Chilean subjects. 〈 i 〉 Methods: 〈 /i 〉 A total of 112 unrelated patients with a diagnosis of CAD confirmed by angiography (33–74 years old) and 107 healthy controls (30–68 years old) were included in this study. PCR-RFLP was used to evaluate the 46C → T polymorphism of the 〈 i 〉 F12 〈 /i 〉 gene. 〈 i 〉 Results: 〈 /i 〉 The genotype distribution for the 46C → T variant of the 〈 i 〉 F12 〈 /i 〉 gene in CAD patients (CC: 41%, CT: 39%, TT: 20%) and controls (CC: 38%, CT: 48%, TT: 14%) was comparable (p = 0.365). Similarly, the allelic frequency was equivalent (p = 0.833). The odds ratio for CAD associated with the mutated 46T allele was 1.06 (95% CI = 0.72–1.56) confirming the absence of an association. 〈 i 〉 Conclusion: 〈 /i 〉 This study showed that the 〈 i 〉 F12 〈 /i 〉 46C → T gene polymorphism is not related to CAD in the studied population. However, this study is limited by its sample size and the use of controls not matched by age and sex.
Type of Medium:
Online Resource
ISSN:
1011-7571
,
1423-0151
Language:
English
Publisher:
S. Karger AG
Publication Date:
2009
detail.hit.zdb_id:
1482963-0
