In:
Digestive Surgery, S. Karger AG, Vol. 26, No. 5 ( 2009), p. 400-405
Kurzfassung:
〈 i 〉 Background: 〈 /i 〉 Colorectal cancer (CRC) patients have an increased risk of developing other malignancies. Understanding the characteristics of the second primary cancer is important to establish an effective surveillance program. 〈 i 〉 Methods: 〈 /i 〉 This study investigated 301 CRC patients to assess the risk factors for postoperative primary cancers arising from organs distinct from the colorectal area (extracolorectal cancers). The observed/expected ratio (O/E ratio) was calculated using the Osaka Cancer Registry, to determine the rate of increase in extracolorectal cancers. 〈 i 〉 Results: 〈 /i 〉 The frequency of postoperative extracolorectal cancers was 12.6%. A logistic regression analysis showed only age to be an independent risk factor for postoperative extracolorectal cancer development. The O/E ratio of overall postoperative extracolorectal cancer was significantly higher than one (O/E ratio 2.6, p 〈 0.01). In each organ, the frequency of lung and gastric cancers were significantly higher than one, with O/E ratios of 3.2 and 2.7 (p 〈 0.01 and p 〈 0.05, respectively). 〈 i 〉 Conclusion: 〈 /i 〉 The frequency of postoperative extracolorectal cancers in CRC patients was significantly higher than that in the normal population, especially for lung and gastric cancers. Clinicians should carefully follow patients for a possible recurrence of CRC and educate CRC patients with regard to the high risk of a second primary cancer.
Materialart:
Online-Ressource
ISSN:
0253-4886
,
1421-9883
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2009
ZDB Id:
1468560-7
