In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 46, No. 5 ( 1974), p. 768-784
Abstract:
Lymphocytes from guinea pigs with delayed cutaneous reactivity to DNP-OA when challenged with this antigen 〈 i 〉 in vitro 〈 /i 〉 elaborated a small molecular weight mediator which is chemotactic for monocytes. The 〈 i 〉 in vitro 〈 /i 〉 production of mononuclear leukocyte (MNL) chemotactic factor (CTX) was carrier specific and appeared to correlate with delayed hypersensitivity. Production of this lymphokine by specific antigen or mitogen-stimulated spleen cells occurred within 8–24 h of incubation, preceding measurable lymphocyte proliferation. MNL CTX was found to be sensitive to proteases and resistant to digestion by neuraminidese. Moreover, MNL CTX was distinguishable from C5 and from other guinea pig lymphokines.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
1974
detail.hit.zdb_id:
1482722-0