In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 71, No. 4 ( 1983), p. 300-303
Kurzfassung:
Blood samples of patients with severe respiratory allergic diseases contain increased numbers of T cells bearing surface HLA-DR antigens, indicating the presence of activated T cells. In the same group of patients, MLR3 and MLR4, two monoclonal antibodies (Mab) directed to subsets of activated peripheral T cells, recognize T cell percentages within the normal range. Thus, it seems possible that specialized subsets of activated T cells (HLA-DR 〈 sup 〉 + 〈 /sup 〉 /MLR3-MLR4 〈 sup 〉 –– 〈 /sup 〉 ) are represented in the peripheral blood of atopic patients. Such cells are lacking in patients after specific imunotherapy. Similar results – an increased percentage of 5/9 〈 sup 〉 + 〈 /sup 〉 T cells in untreated patients and normal counts of 5/9 〈 sup 〉 + 〈 /sup 〉 T cells in treated ones – were obtained in the two groups of patients by using another Mab, 5/9, which serves as a reliable marker of helper T cells in resting peripheral T lymphocytes. These data further support the concept of a T cell imbalance in allergic patients and suggest a possible role of specific immunotherapy in correcting the modification of peripheral T cell abnormalities.
Materialart:
Online-Ressource
ISSN:
1018-2438
,
1423-0097
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1983
ZDB Id:
1482722-0
