In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 82, No. 3-4 ( 1987), p. 317-320
Abstract:
Recently, we reported stimulation of rat macrophages and human platelets by isolated C5b-9 to synthesize prostaglandin E (PGE) or thromboxane B 〈 sub 〉 2 〈 /sub 〉 (TXB 〈 sub 〉 2 〈 /sub 〉 ). In the present study, we tested whether besides prostanoids, C5b-9 also would induce the production of other mediators. We found that C5b-9 in sublytic concentrations stimulated human granulocytes (polymorphonuclear leukocytes) or monocytes to release oxygen radicals. Furthermore, monocytes release interleukin-1 in response to C5b-9. Thus, besides having a lytic capacity, C5b-9 also functions as a stimulator of various cells.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
1987
detail.hit.zdb_id:
1482722-0