In:
Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 70, No. 1 ( 2010), p. 1-7
Kurzfassung:
〈 i 〉 Background/Aims: 〈 /i 〉 To investigate whether the peroxisome proliferator-activated receptor-γ 〈 i 〉 (PPAR- 〈 /i 〉 γ 〈 i 〉 ) 〈 /i 〉 Pro12Ala and the PPAR-γ coactivator-1α 〈 i 〉 (PGC-1 〈 /i 〉 α 〈 i 〉 ) 〈 /i 〉 Gly482Ser polymorphisms were associated with polycystic ovary syndrome (PCOS). 〈 i 〉 Methods: 〈 /i 〉 Genetic analyses of the 〈 i 〉 PPAR- 〈 /i 〉 γ Pro12Ala and the 〈 i 〉 PGC-1 〈 /i 〉 α Gly482Ser polymorphisms were performed in 184 patients with PCOS and 256 controls. Hormone levels, biochemical and clinical features were analyzed according to these polymorphisms. 〈 i 〉 Results: 〈 /i 〉 Neither the 〈 i 〉 PPAR- 〈 /i 〉 γPro12Ala nor the 〈 i 〉 PGC-1 〈 /i 〉 α Gly482Ser polymorphism showed significant differences in genotypic distribution between women with PCOS and controls. In PCOS patients, women with the non-Pro/Pro genotypes of the 〈 i 〉 PPAR- 〈 /i 〉 γ Pro12Ala polymorphism showed statistically significantly higher HDL levels than those with the Pro/Pro genotype (p = 0.002). PCOS patients who had the Ser/Ser genotype of the 〈 i 〉 PGC-1 〈 /i 〉 α Gly482Ser polymorphism had significantly higher levels of postprandial 2-hour insulin than those with the Gly/Ser genotype (p = 0.045). 〈 i 〉 Conclusions: 〈 /i 〉 Neither the 〈 i 〉 PPAR- 〈 /i 〉 γPro12Ala nor the 〈 i 〉 PGC-1 〈 /i 〉 α Gly482Ser polymorphism were supposed to be susceptible genes in PCOS. However, in PCOS patients, the 〈 i 〉 PPAR- 〈 /i 〉 γPro12Ala and the 〈 i 〉 PGC-1 〈 /i 〉 α Gly482Ser polymorphism may modulate the concentrations of serum HDL levels and postprandial 2-hour insulin level, respectively.
Materialart:
Online-Ressource
ISSN:
0378-7346
,
1423-002X
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2010
ZDB Id:
1482695-1
