In:
European Neurology, S. Karger AG, Vol. 63, No. 3 ( 2010), p. 159-163
Abstract:
In order to clarify the immunological characteristics of multiple sclerosis (MS) and neuromyelitis optica (NMO), we analyzed CD3, CD4, CD8, CD20, CD4 〈 sup 〉 + 〈 /sup 〉 CD25 〈 sup 〉 + 〈 /sup 〉 , CD4 〈 sup 〉 + 〈 /sup 〉 CD29 〈 sup 〉 + 〈 /sup 〉 , and CD8 〈 sup 〉 + 〈 /sup 〉 CD11a 〈 sup 〉 high 〈 /sup 〉 cells in peripheral blood from patients with MS (16 stable, 6 active) and NMO (15 stable, 7 active), as well as 9 with NMO spectrum, 6 with clinically isolated syndrome (CIS), and 13 with other neurological diseases using flow cytometry. Significant decreases in the numbers of CD8 〈 sup 〉 + 〈 /sup 〉 CD11a 〈 sup 〉 high 〈 /sup 〉 cells were observed in stable and active MS and CIS. Our findings indicate that CD8 〈 sup 〉 + 〈 /sup 〉 CD11a 〈 sup 〉 high 〈 /sup 〉 cells play different roles in MS and NMO, and their presence may be related to the pathogenesis of MS from the early stage.
Type of Medium:
Online Resource
ISSN:
0014-3022
,
1421-9913
Language:
English
Publisher:
S. Karger AG
Publication Date:
2010
detail.hit.zdb_id:
1482237-4