In:
Medical Principles and Practice, S. Karger AG, Vol. 20, No. 2 ( 2011), p. 171-176
Abstract:
〈 i 〉 Objective: 〈 /i 〉 To investigate the possible association between the codon 72 polymorphism (Pro72Arg, rs1042522) of the tumor suppressor gene 〈 i 〉 (TP53) 〈 /i 〉 and the presence of coronary artery disease (CAD) in Chilean subjects. 〈 i 〉 Subjects and 〈 /i 〉 〈 i 〉 Methods: 〈 /i 〉 A total of 209 unrelated patients with a diagnosis of CAD confirmed by angiography (33–74 years old) and 216 healthy controls (30–68 years old) were included in this study. The Pro72Arg polymorphism of the 〈 i 〉 TP53 〈 /i 〉 gene was evaluated by PCR-RFLP. 〈 i 〉 Results: 〈 /i 〉 The genotype distribution for the Pro72Arg variant of the 〈 i 〉 TP53 〈 /i 〉 gene in CAD patients (PP: n = 13, 6.2%; PR: n = 61, 29.4%; RR: n = 135, 64.6%) and controls (PP: n = 18, 8.3%; PR: n = 94, 43.5%; RR: n = 104, 48.1%) was significantly different (p = 0.003). Similarly, the allelic frequency was also different (p = 0.003). The odds ratio for CAD related to the 72Arg allele was 2.0 (95% CI = 1.33–2.90), confirming the presence of an association. 〈 i 〉 Conclusion: 〈 /i 〉 These findings suggest that the Pro72Arg polymorphism of the 〈 i 〉 TP53 〈 /i 〉 gene is associated with CAD in Chilean individuals.
Type of Medium:
Online Resource
ISSN:
1011-7571
,
1423-0151
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1482963-0
