In:
Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 30, No. 5 ( 2010), p. 381-386
Kurzfassung:
〈 i 〉 Background/Aims: 〈 /i 〉 The present study examined the relationship between microvascular complications and cognitive decline and the development of structural brain abnormalities over a period of 4 years in patients with type 2 diabetes mellitus (T2DM). 〈 i 〉 Methods: 〈 /i 〉 Sixty-eight elderly patients with T2DM had 2 cognitive assessments with a 4-year interval. Two MRI scans, performed at the same time as the cognitive assessments, were available from 55 patients. Changes in cognitive performance over time were expressed as a regression-based index (RBI). Automated volumetric measurements of total brain, lateral ventricles and white matter hyperintensities were performed. The relationship between baseline microvascular complications [diabetic retinopathy, peripheral neuropathy or albuminuria (micro- or macroalbuminuria)] and cognition and brain volumes was examined with linear regression analyses adjusted for age and sex (for cognition also for IQ). 〈 i 〉 Results: 〈 /i 〉 At baseline, diabetic retinopathy was present in 18% of patients, peripheral neuropathy in 36%, albuminuria in 15%. Retinopathy or neuropathy were not significantly associated with baseline cognition or brain volumes, or changes in these measures over time. Albuminuria was associated with a lower composite RBI score, indicating accelerated cognitive decline (adjusted mean difference between patients with or without albuminuria: –0.58, 95% CI –0.85 to –0.31, p 〈 0.001). 〈 i 〉 Conclusion: 〈 /i 〉 Albuminuria predicted accelerated cognitive decline in patients with T2DM, but other microvascular complications were unrelated to accelerated cognitive decline or brain MRI abnormalities.
Materialart:
Online-Ressource
ISSN:
1420-8008
,
1421-9824
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2010
ZDB Id:
1482186-2
