In:
Journal of Innate Immunity, S. Karger AG, Vol. 3, No. 4 ( 2011), p. 420-434
Abstract:
The CD6 scavenger receptor is known to be expressed on virtually all T cells and is supposed to be involved in costimulation, synapse formation, thymic selection and leukocyte migration. Here, we demonstrate that CD6 is differentially expressed by a subpopulation of peripheral CD56 〈 sup 〉 dim 〈 /sup 〉 natu- ral killer (NK) cells and absent on CD56 〈 sup 〉 bright 〈 /sup 〉 NK cells. CD56 〈 sup 〉 dim 〈 /sup 〉 CD16 〈 sup 〉 + 〈 /sup 〉 cells represent the major NK subset in the periphery, and most cells within this group are positive for CD6. Most killer immunoglobulin-like receptor- and immunoglobulin-like transcript-positive cells also belong to the CD6 〈 sup 〉 + 〈 /sup 〉 subpopulation, as expected from their restricted expression on CD56 〈 sup 〉 dim 〈 /sup 〉 NK cells. In addition, CD6 〈 sup 〉 + 〈 /sup 〉 NK cells are similar to the newly identified CD94 〈 sup 〉 low 〈 /sup 〉 CD56 〈 sup 〉 dim 〈 /sup 〉 NK subpopulation and most distant from the recently defined CD27 〈 sup 〉 + 〈 /sup 〉 NK subpopulation based on the reverse correlation of expression between CD6 and CD27, a marker associated primarily with CD56 〈 sup 〉 bright 〈 /sup 〉 NK cells. With respect to CD6 function on NK cells, direct CD6 triggering did not result in degranulation but induced secretion of cytokines (interferon-γ and tumor necrosis factor-α) and chemokines [CXCL10 (IP-10), CXCL1 (GRO-α)]. Thus, CD6 expression on peripheral NK c ells marks a novel CD56 〈 sup 〉 dim 〈 /sup 〉 subpopulation associated with distinct patterns of cytokine and chemokine secretion.
Type of Medium:
Online Resource
ISSN:
1662-811X
,
1662-8128
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
2455818-7
