In:
European Surgical Research, S. Karger AG, Vol. 46, No. 3 ( 2011), p. 139-147
Abstract:
〈 i 〉 Purpose: 〈 /i 〉 Hyperthermic intraperitoneal chemotherapy is continuously under evaluation in ovarian cancer. The purpose of the present study was to evaluate the effect of chemotherapy, drug concentration and temperature. 〈 i 〉 Materials and Methods: 〈 /i 〉 A human ovarian carcinoma cell line was used. The effect of hyperthermia combined with chemotherapy was analyzed. 〈 i 〉 Results: 〈 /i 〉 When hyperthermia was combined with chemotherapy, the 50% lethal dose (LD 〈 sub 〉 50 〈 /sub 〉 ) decreased with the duration of exposure. The effect of temperature was similar between 39 and 43°C for a 30-min exposure. For a 60- to 90-min exposure, the LD 〈 sub 〉 50 〈 /sub 〉 was equivalent between 38 and 43°C. Beyond 40°C, an increase in platinum salt concentration was necessary to obtain similar results according to the duration of exposure. 〈 i 〉 Conclusions: 〈 /i 〉 The cytotoxic effect of the combination seemed to be potentiated and limited at 40°C.
Type of Medium:
Online Resource
ISSN:
0014-312X
,
1421-9921
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1468505-X