In:
Neuroepidemiology, S. Karger AG, Vol. 36, No. 4 ( 2011), p. 213-222
Abstract:
〈 i 〉 Background: 〈 /i 〉 An Icelandic study showed a significant positive association between phosphodiesterase 4D 〈 i 〉 (PDE4D) 〈 /i 〉 gene variants and stroke. However, subsequent studies reported conflicting results, possibly due to small sample sizes and the heterogeneity of the studies. 〈 i 〉 Method: 〈 /i 〉 We performed a meta-analysis on 6 SNPs of the 〈 i 〉 PDE4D 〈 /i 〉 gene to investigate the association between this gene and ischemic stroke by integrating the results of previous studies, comprising 11,834 cases and 15,233 controls. A pooled genotypic odds ratio (OR) for each SNP was determined under 3 genetic models (i.e. dominant, recessive, and codominant) using both fixed- and random-effects models with consideration for heterogeneity and publication bias across studies. 〈 i 〉 Results: 〈 /i 〉 Among the SNPs included in this study, SNP56 (rs702553) showed the most significant association with ischemic stroke in a meta-analysis comprised of 7 homogenous studies. The overall OR of the TT genotype compared to the AA genotype was 1.29 (95% CI 1.03–1.61; p = 0.022). For SNP83 (rs966221), a protective effect of the ancestral allele T was observed only in Asian populations (ORTT 0.79, 95% CI 0.69–0.90; p = 0.0005). This meta-analysis revealed a significant association of 〈 i 〉 PDE4D 〈 /i 〉 gene variants with the risk of ischemic stroke, and further investigations are warranted to evaluate possible ethnic-specific effects.
Type of Medium:
Online Resource
ISSN:
0251-5350
,
1423-0208
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
1483032-2
