In:
Cerebrovascular Diseases, S. Karger AG, Vol. 33, No. 2 ( 2012), p. 150-158
Abstract:
〈 i 〉 Background: 〈 /i 〉 Lipoprotein-associated phospholipase A 〈 sub 〉 2 〈 /sub 〉 (Lp-PLA 〈 sub 〉 2 〈 /sub 〉 ) has emerged as a novel biomarker in cardiovascular diseases due to its ability to predict stroke in population-based studies. We aimed to investigate Lp-PLA 〈 sub 〉 2 〈 /sub 〉 levels in transient ischemic attack (TIA) patients and to study their relationship with stroke recurrence. 〈 i 〉 Methods: 〈 /i 〉 Lp-PLA 〈 sub 〉 2 〈 /sub 〉 mass and activity were measured by means of the PLAC test with an automated Olympus analyzer and by a colorimetric activity method (diaDexus) in 166 TIA patients and 144 healthy controls. Vascular risk factors and stroke etiology were assessed. Outcome was defined as the presence of recurrent stroke/TIA within 7 and 30 days after the index TIA. Multivariate analyses were performed to identify potential predictors of recurrence. 〈 i 〉 Results: 〈 /i 〉 Both Lp-PLA 〈 sub 〉 2 〈 /sub 〉 mass and activity (p 〈 0.05) were higher in TIA than in controls. Several risk factors or previous treatments were associated with Lp-PLA 〈 sub 〉 2 〈 /sub 〉 mass and activity level. During follow-up, 20 strokes/TIA (12%) occurred within the first 30 days and the presence of a large-artery atherosclerosis etiology of stroke (HR 3.28, p = 0.011), together with the past medical history of hyperlipidemia (HR 3.68, p = 0.008) and Lp-PLA 〈 sub 〉 2 〈 /sub 〉 activity of 〉 207 nmol/ml/min (HR 2.7, p = 0.042) were all significant predictors for recurrent stroke/TIA. 〈 i 〉 Conclusions: 〈 /i 〉 Lp-PLA 〈 sub 〉 2 〈 /sub 〉 activity might add significant prognostic information in the early evaluation of TIA patients.
Type of Medium:
Online Resource
ISSN:
1015-9770
,
1421-9786
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1482069-9
