In:
Lifestyle Genomics, S. Karger AG, Vol. 4, No. 6 ( 2011), p. 354-366
Abstract:
〈 i 〉 Background/Aims: 〈 /i 〉 The peroxisome proliferator-activated receptors (PPARs) are transcriptional regulators of lipid metabolism, activated by unsaturated fatty acids. We investigated independent and interactive effects of PPARγ2 gene 〈 i 〉 PPARG 〈 /i 〉 Pro12Ala (rs1801282) andPPARαgene 〈 i 〉 PPARA 〈 /i 〉 Leu162Val (rs1800206) genotypes with dietary intake of fatty acids on concentrations of plasma lipids in subjects of whom 47.5% had metabolic syndrome. 〈 i 〉 Methods: 〈 /i 〉 The RISCK study is a parallel design, randomised controlled trial. Plasma lipids were quantified at baseline after a 4-week high saturated fatty acids diet and after three parallel 24-week interventions with reference (high saturated fatty acids), high monounsaturated fatty acids and low-fat diets. Single nucleotide polymorphisms were genotyped in 466 subjects. 〈 i 〉 Results: 〈 /i 〉 At baseline, the 〈 i 〉 PPARG 〈 /i 〉 Ala12allele was associated with increased plasma total cholesterol (n = 378; p = 0.04), LDL cholesterol (p = 0.05) and apoB (p =0.05) after adjustment for age, gender and ethnicity. At baseline, 〈 i 〉 PPARA 〈 /i 〉 Leu162Val × 〈 i 〉 PPARG 〈 /i 〉 Pro12Ala genotype interaction did not significantly influence plasma lipid concentrations. After dietary intervention, gene-gene interaction significantly influenced LDL cholesterol (p =0.0002) and small dense LDL as a proportion of LDL (p = 0.005) after adjustments. 〈 i 〉 Conclusions: 〈 /i 〉 Interaction between 〈 i 〉 PPARG 〈 /i 〉 Pro12Ala and 〈 i 〉 PPARA 〈 /i 〉 Leu162Valgenotypes may influence plasma LDL cholesterol concentration and the proportion as small dense LDL after a high monounsaturated fatty acids diet.
Type of Medium:
Online Resource
ISSN:
2504-3161
,
2504-3188
Language:
English
Publisher:
S. Karger AG
Publication Date:
2011
detail.hit.zdb_id:
2908437-4
