In:
Respiration, S. Karger AG, Vol. 86, No. 2 ( 2013), p. 109-116
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 To date, no clinical parameter has been associated with the decline in lung function other than emphysema severity in COPD. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The main purpose of this study was to explore whether the rate of lung function decline differs between COPD patients with and without exertional desaturation. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 224 subjects were selected from the Korean Obstructive Lung Disease cohort. Exertional desaturation was assessed using the 6-min walk test (6MWT), and defined as a post-exercise oxygen saturation (Sp 〈 smlcap 〉 O 〈 /smlcap 〉 〈 sub 〉 2 〈 /sub 〉 ) of 〈 90% or a ≥4% decrease. The cohort was divided into desaturator (n = 47) and non-desaturator (n = 177) groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There was a significant difference between the desaturator and non-desaturator groups in terms of the change in pre-bronchodilator forced expiratory volume in 1 s (FEV 〈 sub 〉 1 〈 /sub 〉 ) over a 3-year period of follow-up (p = 0.006). The mean rate of decline in FEV 〈 sub 〉 1 〈 /sub 〉 was greater in the desaturator group (33.8 ml/year) than in the non-desaturator group (11.6 ml/year). A statistically significant difference was also observed between the two groups in terms of the change in the St. George's Respiratory Questionnaire (SGRQ) total score over 3 years (p = 0.001). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This study suggests, for the first time, that exertional desaturation may be a predictor of rapid decline in lung function in patients with COPD. The 6MWT may be a useful test to predict a rapid lung function decline in COPD.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
2013
detail.hit.zdb_id:
1464419-8
