In:
Dementia and Geriatric Cognitive Disorders, S. Karger AG, Vol. 37, No. 5-6 ( 2014), p. 294-306
Kurzfassung:
〈 b 〉 〈 i 〉 Aims: 〈 /i 〉 〈 /b 〉 To evaluate the relationship between self-reported head injury and cognitive impairment, dementia, mortality, and Alzheimer's disease (AD)-type pathological changes. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Clinical and neuropathological data from participants enrolled in a longitudinal study of aging and cognition (n = 649) were analyzed to assess the chronic effects of self-reported head injury. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The effect of self-reported head injury on the clinical state depended on the age at assessment: for a 1-year increase in age, the OR for the transition to clinical mild cognitive impairment (MCI) at the next visit for participants with a history of head injury was 1.21 and 1.34 for the transition from MCI to dementia. Without respect to age, head injury increased the odds of mortality (OR = 1.54). Moreover, it increased the odds of a pathological diagnosis of AD for men (OR = 1.47) but not women (OR = 1.18). Men with a head injury had higher mean amyloid plaque counts in the neocortex and entorhinal cortex than men without. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Self-reported head injury is associated with earlier onset, increased risk of cognitive impairment and dementia, increased risk of mortality, and AD-type pathological changes.
Materialart:
Online-Ressource
ISSN:
1420-8008
,
1421-9824
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2014
ZDB Id:
1482186-2