In:
Urologia Internationalis, S. Karger AG, Vol. 93, No. 2 ( 2014), p. 207-213
Kurzfassung:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 In patients with bladder cancer (BCa) preoperative staging with 〈 sup 〉 11 〈 /sup 〉 C-choline positron emission tomography-computed tomography (PET/CT) could be used to derive prognostic information and hence stratify patients preoperatively with respect to disease management. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 From June 2004 to May 2007, 44 patients with localized BCa were staged with 〈 sup 〉 11 〈 /sup 〉 C-choline PET/CT before radical cystectomy. The results of imaging were correlated to overall survival (OS) and cumulative incidence of cancer-specific death (CSD). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There was no statistically significant difference in OS and CSD between the patient groups when stratified for organ-confined versus non-organ-confined disease or lymph node involvement defined by either 〈 sup 〉 11 〈 /sup 〉 C-choline PET/CT (OS: p = 0.262, hazard ratio [HR] = 1.60; p = 0.527, HR = 0.76; CSD: p = 0.144, HR = 2.25; p = 0.976, HR = 0.98) or CT (OS: p = 0.518, HR = 1.34; p = 0.228, HR = 1.67; CSD: p = 0.323, HR = 1.90; p = 0.136, HR = 2.38). The limitation of this study is the small number of included patients. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 In our prospective trial neither CT nor 〈 sup 〉 11 〈 /sup 〉 C-choline PET/CT were able to sufficiently predict OS or CSD in BCa patients treated with radical cystectomy albeit trends and moderately increased HRs could be demonstrated without significant differences between CT or 〈 sup 〉 11 〈 /sup 〉 C-choline PET/CT. However, these trends might prove statistically significant in bigger patient cohorts. Therefore initial transsectional imaging might be of clinical relevance in respect to prognosis and could play a role in the counseling of BCa patients.
Materialart:
Online-Ressource
ISSN:
0042-1138
,
1423-0399
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2014
ZDB Id:
1464417-4
