In:
Oncology Research and Treatment, S. Karger AG, Vol. 37, No. 3 ( 2014), p. 106-110
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The single nucleotide polymorphism (SNP) rs1465618 in 〈 i 〉 THADA 〈 /i 〉 at 2p21 has been identified as being associated with prostate cancer (PCa) risk in Europeans; however, it is not clear whether the SNP is related to PCa risk in multiple populations. We investigated the association of rs1465618 in 〈 i 〉 THADA 〈 /i 〉 with PCa in a Chinese population and carried out a meta-analysis in multiple populations, testing the relevance of this SNP for PCa risk. 〈 b 〉 〈 i 〉 Patients and Methods: 〈 /i 〉 〈 /b 〉 We genotyped the SNP using high resolution melting (HRM) analysis and assessed its association with PCa risk in a case-control study of 289 PCa patients and 288 controls in a Chinese population. A meta-analysis was carried out with 36,313 PCa patients and 36,485 controls to evaluate the association of rs1465618 with PCa risk in multiple populations. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 rs1465618 in 〈 i 〉 THADA 〈 /i 〉 was significantly associated with PCa risk (p = 0.026; odds ratio (OR) 1.327, 95% confidence interval (CI) 1.035-1.700). Furthermore, the rs1465618 variant genotype was associated with PCa aggressiveness (p = 0.044; OR = 2.053, 95% CI = 1.015-6.602) in the Chinese population. The meta-analysis showed that rs1465618 was significantly associated with PCa risk in multiple populations (p = 1.0×10 〈 sup 〉 -8 〈 /sup 〉 ; OR = 1.127, 95% CI = 1.085-1.171). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our results showed that rs1465618 in 〈 i 〉 THADA 〈 /i 〉 may be a shared susceptibility variant for PCa in multiple populations. 〈 i 〉 THADA 〈 /i 〉 gene polymorphisms may impact PCa susceptibility and progression.
Type of Medium:
Online Resource
ISSN:
2296-5270
,
2296-5262
Language:
English
Publisher:
S. Karger AG
Publication Date:
2014
detail.hit.zdb_id:
2749752-5
