In:
Transfusion Medicine and Hemotherapy, S. Karger AG, Vol. 41, No. 3 ( 2014), p. 176-181
Kurzfassung:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Gamma irradiation is currently the standard care to avoid transfusion-associated graft-versus-host disease. Guidelines on gamma irradiation of blood components state that platelets (PLTs) can be irradiated at any stage in their 5-day storage and can thereafter be stored up to their normal shelf life of 5 days after collection. In this study, we explored whether the timing of irradiation has an effect on transfusion efficacy of apheresis PLT concentrates (APCs). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Based on the 1-hour percent PLT recovery (PPR 〈 sub 〉 1h 〈 /sub 〉 ), transfusion efficacy of 1,000 eligible APCs transfused to 144 children were evaluated retrospectively. PPR 〈 sub 〉 1h 〈 /sub 〉 was compared in transfused APCs irradiated at the day of transfusion and APCs irradiated in advance. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In univariate analysis, transfusion efficacy of APCs irradiated in advance was significantly lower than that of APCs irradiated at the day of transfusion (mean PPR 〈 sub 〉 1h 〈 /sub 〉 27.7 vs. 35.0%; p = 0.007). This was confirmed in multivariate analysis (p = 0.030). Compared to non-irradiated APCs, transfusion efficacy of APCs irradiated at the day of transfusion was not significantly inferior (mean difference -2.8%; 95% CI -6.1 to 0.5%; p = 0.092), but APCs irradiated in advance were clearly less efficient (mean difference -8.1%; 95% CI -12.2 to -4.0%; p 〈 0.001). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our data strongly support that APCs should not be irradiated in advance, i.e., ≥24 h before transfusion.
Materialart:
Online-Ressource
ISSN:
1660-3796
,
1660-3818
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2014
ZDB Id:
2100533-3
