In:
Blood Purification, S. Karger AG, Vol. 40, No. 2 ( 2015), p. 139-145
Kurzfassung:
This study aimed to assess cardiac troponin T (cTnT) and hydration state as cardiovascular (CV) risk markers in hemodialysis (HD) patients. Two hundred and forty one patients were divided according to HD vintage into two groups: SV (HD ≤24 months) and LV. Water balance was assessed with overhydration (OH%; bioimpedance analysis) and daily diuresis (DD); CV dysfunction with cTnT and heart ultrasound; nutrition with subjective global assessment (SGA), cholesterol (TC) and albumin. SV had lower OH% (2.8 vs. 3.5, p 〈 0.05) and higher DD (1,161 vs. 637 ml, p 〈 0.001), while LV had higher cTnT (0.1 ± 0.04 vs. 0.1 ± 0.07 ng/ml, p 〈 0.05) and lower interventricular septum thickness (IVS; 13.4 vs. 14.5 mm, p 〈 0.05). Nutritional state as reflected by lower TC was worse in LV (184.7 vs. 169.5 mg/dl, p 〈 0.05). Mortality was higher in patients in the LV group (15 vs. 27 deaths, p 〈 0.05). OH% correlated inversely with albumin (r = -0.36, p 〈 0.001), TC (r = -0.31, p 〈 0.001) and cTnT (r = -0.4, p 〈 0.001). cTnT correlated positively with IVS (r = 0.39, p 〈 0.001), SGA (r = 0.23, p = 0.001) and mortality rate (r = 0.21, p 〈 0.01), and negatively with DD (r = -0.34, p 〈 0.001) and albumin (r = -0.25, p 〈 0.001). Longer dialysis vintage associates with CV dysfunction, overhydration and increased mortality, which may be predicted with OH% and cTnT. Video Journal Club ‘Cappuccino with Claudio Ronco' at http://www.karger.com/?doi=376603.
Materialart:
Online-Ressource
ISSN:
0253-5068
,
1421-9735
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2015
ZDB Id:
1482025-0
