In:
Ophthalmic Research, S. Karger AG, Vol. 58, No. 2 ( 2017), p. 117-124
Abstract:
〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 We present the multifocal electroretinogram (mfERG) with a 7-hexagon array as an objective test of macular function that can be recorded in 14 s. We provide normal values and investigate its reproducibility and validity. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Healthy participants underwent mfERG testing according to International Society for Clinical Electrophysiology of Vision (ISCEV) standards using the Espion Profile/D310 multifocal ERG system (Diagnosys, LLC, Lowell, MA, USA). One standard recording of a 61-hexagon array and 2 repeated recordings of a custom 7-hexagon array were obtained. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 13 subjects (mean age 46.9 years) were included. The median response densities were 12.5 nV/deg 〈 sup 〉 2 〈 /sup 〉 in the center and 5.2 nV/deg 〈 sup 〉 2 〈 /sup 〉 in the periphery. Intereye correlations were strong in both the center ( & #x03C1; 〈 sub 〉 Center 〈 /sub 〉 = 0.821; 〈 i 〉 p 〈 /i 〉 〈 0.0001) and the periphery ( & #x03C1; 〈 sub 〉 Periphery 〈 /sub 〉 = 0.862; 〈 i 〉 p 〈 /i 〉 〈 0.0001). Intraeye correlations were even stronger: & #x03C1; 〈 sub 〉 Center 〈 /sub 〉 = 0.904 with 〈 i 〉 p 〈 /i 〉 〈 0.0001 and & #x03C1; 〈 sub 〉 Periphery 〈 /sub 〉 = 0.955 with 〈 i 〉 p 〈 /i 〉 〈 0.0001. Bland-Altman plots demonstrated an acceptable retest mean difference in both the center and periphery, and narrow limits of agreement. We found strong correlations of the center ( & #x03C1; 〈 sub 〉 Center 〈 /sub 〉 = 0.826; 〈 i 〉 p 〈 /i 〉 〈 0.0001) and periphery ( & #x03C1; 〈 sub 〉 Periphery 〈 /sub 〉 = 0.848; 〈 i 〉 p 〈 /i 〉 〈 0.0001), with recordings obtained by the 61-hexagon method. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 The 7-hexagon mfERG provides reproducible results in agreement with results obtained according to the ISCEV standard.
Type of Medium:
Online Resource
ISSN:
0030-3747
,
1423-0259
Language:
English
Publisher:
S. Karger AG
Publication Date:
2017
detail.hit.zdb_id:
1483177-6
