In:
Digestive Diseases, S. Karger AG, Vol. 35, No. 6 ( 2017), p. 506-514
Abstract:
〈 b 〉 〈 i 〉 Aim: 〈 /i 〉 〈 /b 〉 Acute-onset autoimmune hepatitis (AIH) histopathologically presents with features of acute hepatitis and lacks a specific diagnostic method. Also, AIH is often difficult to differentiate from drug-induced liver injury (DILI). We aimed to investigate the final clinical diagnosis of these cases, and compare the clinical, biochemical, and histological characteristics of AIH vs. DILI. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We examined the Digestive Disease Week Japan 2004 (DDW-J) scale scores, AIH scores, clinical data, and pathological findings in 20 patients in whom it was difficult to differentiate autoimmune liver disease from DILI. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In cases with a DDW-J scale score of ≥5, there was a good correlation between the final diagnosis and DDW-J scale assessments, but in cases with a DDW-J scale score of & #x2266;4 they did not correlate well. The scores for pathological findings, such as cobblestone hepatocellular change ( 〈 i 〉 p 〈 /i 〉 = 0.015), interface hepatitis ( 〈 i 〉 p 〈 /i 〉 = 0.012), and prominent plasma cells in portal areas ( 〈 i 〉 p 〈 /i 〉 = 0.011), were higher in the AIH group than in the DILI group. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 This study showed that DDW-J scale was useful for differentiating AIH from DILI in cases with a DDW-J scale score of & #x2267;5. The histologic features of AIH were characterized by cobblestone hepatocellular change, interface hepatitis, and plasma cell infiltration of the portal region.
Type of Medium:
Online Resource
ISSN:
0257-2753
,
1421-9875
Language:
English
Publisher:
S. Karger AG
Publication Date:
2017
detail.hit.zdb_id:
1482221-0
