In:
Neonatology, S. Karger AG, Vol. 113, No. 4 ( 2018), p. 347-352
Kurzfassung:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Withholding enteral feedings during hypothermia lacks supporting evidence. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 We aimed to determine if minimal enteral nutrition (MEN) during hypothermia in patients with hypoxic-ischemic encephalopathy was associated with a reduced duration of parenteral nutrition, time to full oral feeds, and length of stay, but would not be associated with increased systemic inflammation or feeding complications. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We performed a pilot, retrospective, matched case-control study within the Florida Neonatal Neurologic Network from December 2012 to May 2016 of patients who received MEN during hypothermia ( 〈 i 〉 n 〈 /i 〉 = 17) versus those who were not fed ( 〈 i 〉 n 〈 /i 〉 = 17). Length of stay, feeding-related outcomes, and brain injury identified by MRI were compared. Serum inflammatory mediators were measured at 0–6, 24, and 96 h of life by multiplex assay. MRI were scored using the Barkovich system. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 MEN subjects had a reduced length of hospital stay (mean 15 ± 11 vs. 24 ± 19 days, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05), days receiving parenteral nutrition (7 ± 2 vs. 11 ± 6, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05), and time to full oral feeds (8 ± 5 vs. 18 ± 18, 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05). MEN was associated with a significantly reduced serum IL-12p70 at 24 and 96 h ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.05). Brain MRI scores were not significantly different between groups. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 MEN during hypothermia was associated with a reduced length of stay and time to full feeds, but did not increase feeding complications or systemic inflammation.
Materialart:
Online-Ressource
ISSN:
1661-7800
,
1661-7819
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2018
ZDB Id:
2403535-X
SSG:
12
