In:
Respiration, S. Karger AG, Vol. 96, No. 1 ( 2018), p. 29-40
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Diabetes mellitus is a significant comorbidity of interstitial lung disease (ILD). 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The aim of this study was to investigate the incidence of restrictive lung disease (RLD) and ILD in patients with prediabetes and type 2 diabetes (T2D). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Forty-eight nondiabetics, 68 patients with prediabetes, 29 newly diagnosed T2D, and 110 patients with long-term T2D were examined for metabolic control, diabetes-related complications, breathlessness, and lung function. Five participants with T2D, breathlessness, and RLD underwent multidetector computed tomography (MDCT) and a Six-Minute Walk Test (6MWT). Lung tissue from 4 patients without diabetes and from 3 patients with T2D was histologically examined for presence of pulmonary fibrosis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Breathlessness in combination with RLD was significantly increased in patients with prediabetes and T2D ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.01). RLD was found in 9% of patients with prediabetes, in 20% of patients with newly diagnosed T2D, and in 27% of patients with long-term T2D. Thus, patients with long-term T2D had an increased risk of RLD (OR 5.82 [95% CI 1.71–20.5], 〈 i 〉 p 〈 /i 〉 & #x3c; 0.01). RLD was significantly associated with glucose metabolism and albuminuria ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.01); furthermore, presence of nephropathy increased the risk of RLD (OR 8.57 [95% CI 3.4–21.9], 〈 i 〉 p 〈 /i 〉 & #x3c; 0.01) compared to nondiabetics. MDCT revealed ILD in 4 patients, the 6MWT correlated with the extent of ILD, and histological analysis showed fibrosing ILD in patients with T2D. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This study demonstrates increased breathlessness and a high prevalence of RLD in patients with T2D, indicating an association between diabetes and fibrosing ILD.
Type of Medium:
Online Resource
ISSN:
0025-7931
,
1423-0356
Language:
English
Publisher:
S. Karger AG
Publication Date:
2018
detail.hit.zdb_id:
1464419-8
