In:
Digestive Diseases, S. Karger AG, Vol. 37, No. 6 ( 2019), p. 467-472
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 〈 i 〉 Clostridium difficile 〈 /i 〉 is a gram-positive, anaerobic, and spore-forming bacillus, which is responsible for the majority of antibiotic-associated diarrhea and colitis. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 Determine if fecal microbiota transplantation (FMT) is effective in a population sample from Connecticut. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We report the clinical experience of 92 consecutive patients from one gastroenterology practice in central Connecticut treated by colonoscopy with FMT for infection with 〈 i 〉 Clostridium difficile 〈 /i 〉 from 2012 to 2017. The analyses are based on clinical follow-up up to 3 months after the FMT procedure and on medical chart review. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Overall, complete recovery occurred in 86% of patients. As previously reported in a limited number of previous studies, community-acquired cases were more common than hospital-acquired cases, and community-acquired cases were more likely to be female. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Consistent with some previous reports, we found the following: the source of the donor for FMT did not make a difference in recovery: material from nonrelatives was as effective as from close relatives; and the presence of multiple comorbidities did not make a difference in recovery: patients with 2 or more comorbidities did as well as those with one or none.
Type of Medium:
Online Resource
ISSN:
0257-2753
,
1421-9875
Language:
English
Publisher:
S. Karger AG
Publication Date:
2019
detail.hit.zdb_id:
1482221-0
