In:
Neonatology, S. Karger AG, Vol. 118, No. 6 ( 2021), p. 727-733
Kurzfassung:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Data on valid incidence estimates of perinatal arterial ischemic stroke (PAIS) are scarce. This analysis aims to determine incidence of PAIS in term- and preterm-born infants and to investigate clinical differences related to prematurity. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This surveillance study (2015–2017) in all German paediatric hospital estimated incidences for MRI-confirmed PAIS in term and preterm infants. To correct for under-reporting, we performed capture-recapture-calculations (CRC) in the most populous federal state and extrapolated nationwide. Differences in clinical presentation in term- and preterm-born infants were assessed. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 126 term- and 19 preterm-born infants with PAIS were reported. CRC corrected incidence of PAIS was 22 (95% confidence interval [CI] 17, 27) per 100,000 live births. Stratified by prematurity, the incidence was 32 (95% CI 15, 49) per 100,000 in preterm-born infants and 21 (95% CI 16, 26) per 100,000 term-born infants (significant difference 〈 i 〉 p 〈 /i 〉 = 0.001). In symptomatic cases only ( 〈 i 〉 n 〈 /i 〉 = 120 term born, 〈 i 〉 n 〈 /i 〉 = 12 preterm born), incidences did not differ. Risk factor patterns were similar, but number of risk factors in preterm babies was elevated (mean 3.8 vs. 2.9; 〈 i 〉 p 〈 /i 〉 = 0.01) and median age at diagnosis was increased (5 vs. 3 days; 〈 i 〉 p 〈 /i 〉 = 0.04). Clinical seizures were observed in 88% (106/120) of symptomatic term infants compared to 33% (4/12) in preterm-born infants ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 PAIS incidence rates in Germany, extrapolated from estimates for completeness of reporting in the largest federal state, were within the range of other population-based studies. As a novel finding, we detected symptomatic PAIS in preterm-born infants to be as common as in term-born infants although their symptoms were often unspecific.
Materialart:
Online-Ressource
ISSN:
1661-7800
,
1661-7819
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2021
ZDB Id:
2403535-X
SSG:
12
