In:
Dermatology, S. Karger AG, Vol. 237, No. 4 ( 2021), p. 506-512
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 〈 i 〉 Staphylococcus aureus 〈 /i 〉 colonization is associated with disease severity in patients with atopic dermatitis (AD). 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 To investigate temporal variation in 〈 i 〉 S. aureus 〈 /i 〉 protein A gene ( 〈 i 〉 spa) 〈 /i 〉 -types isolated from the nose and lesional skin and the correlation of 〈 i 〉 spa 〈 /i 〉 -types with disease severity. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 This study included 96 adult AD patients who were assessed at baseline (T0) and after a strict 2-week follow-up period (T1) in which treatment was standardized with a topical corticosteroid. Fifty-five different 〈 i 〉 spa 〈 /i 〉 -types were detected in the nose and skin cultures. Seventy-three patients were colonized with 〈 i 〉 S. aureus 〈 /i 〉 in the nasal cavity at both time points (persistent carriership), 59 of whom (81%) had identical 〈 i 〉 spa 〈 /i 〉 -types over time. For skin samples, 42 (75%) of the 56 persistent skin carriers had identical 〈 i 〉 spa 〈 /i 〉 -types over time. The same 〈 i 〉 spa 〈 /i 〉 -type was carried in the nose and skin in 79 and 77% of the patients at T0 and T1, respectively. More severe disease was not associated with specific 〈 i 〉 spa 〈 /i 〉 -types or with temporal variation in 〈 i 〉 spa 〈 /i 〉 -type. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 〈 i 〉 S. aureus 〈 /i 〉 strains in AD are highly heterogeneous between patients. The majority of patients carry the same 〈 i 〉 spa 〈 /i 〉 -type in the nose and skin without temporal variation, suggesting clonal colonization within individual patients. No predominant 〈 i 〉 spa 〈 /i 〉 -type or temporal variation is associated with increased disease severity.
Type of Medium:
Online Resource
ISSN:
1018-8665
,
1421-9832
Language:
English
Publisher:
S. Karger AG
Publication Date:
2021
detail.hit.zdb_id:
1482189-8
