In:
European Neurology, S. Karger AG, Vol. 84, No. 6 ( 2021), p. 435-443
Kurzfassung:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 This study aimed to use a novel MRI contrast, the standardized T1-weighted/T2-weighted (sT1w/T2w) ratio, to assess damage of the white matter and gray matter in multiple system atrophy (MSA). Furthermore, this study investigated whether the sT1w/T2w ratio was associated with cognitive impairment in MSA. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The white matter and gray matter sT1w/T2w ratio of 37 MSA patients and 19 healthy controls were measured. Correlation analyses were used to evaluate the relationship between sT1w/T2w ratio values and clinical variables, and a multivariate analysis was used to identify independent factors associated with cognitive impairment in MSA. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 MSA patients showed a higher white matter sT1w/T2w ratio value than controls ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), and the white matter sT1w/T2w ratio value was significantly correlated with the International Cooperative Ataxia Rating Scale score ( 〈 i 〉 r 〈 /i 〉 = 0.377, 〈 i 〉 p 〈 /i 〉 = 0.021) and the Addenbrooke’s cognitive examination III score ( 〈 i 〉 r 〈 /i 〉 = −0.438, 〈 i 〉 p 〈 /i 〉 = 0.007). Cognitively impaired MSA patients had a significantly higher white matter sT1w/T2w ratio value than cognitively preserved MSA patients ( 〈 i 〉 p 〈 /i 〉 = 0.010), and the multiple logistic regression analysis revealed that the median white matter sT1w/T2w ratio value was independently associated with cognitive impairment in MSA. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The sT1w/T2w ratio is sensitive to degenerative changes in the white matter that is associated with cognitive ability in MSA patients.
Materialart:
Online-Ressource
ISSN:
0014-3022
,
1421-9913
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2021
ZDB Id:
1482237-4
