In:
International Archives of Allergy and Immunology, S. Karger AG, Vol. 183, No. 1 ( 2022), p. 116-126
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 The aim of this study was to assess the differences between childhood-onset and adult-onset systemic lupus erythematosus (cSLE and aSLE) for clinical manifestations and mortality using a meta-analytic approach. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The PubMed, EMBASE, and the Cochrane library were searched for eligible studies published between January 1982 and March 2021. The odds ratio (OR) with 95% confidence interval was used to calculate the pooled effect estimates using the random-effects model. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Thirty-four studies involving 21,946 SLE patients were included. cSLE was associated with an increased risk of malar rash (OR: 1.64; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), ulcers/mucocutaneous involvement (OR: 1.22; 〈 i 〉 p 〈 /i 〉 = 0.039), general neurological involvement (OR: 1.52; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), seizures (OR: 1.92; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), general renal involvement (OR: 2.08; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), proteinuria (OR: 1.35; 〈 i 〉 p 〈 /i 〉 = 0.015), urinary cellular casts (OR: 1.67; 〈 i 〉 p 〈 /i 〉 = 0.047), fever (OR: 2.31; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), anemia (OR: 1.91; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), thrombocytopenia (OR: 1.41; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), leucopenia (OR: 1.57; 〈 i 〉 p 〈 /i 〉 = 0.017), lymphadenopathy (OR: 2.40; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001), and cutaneous vasculitis (OR: 1.72; 〈 i 〉 p 〈 /i 〉 = 0.001) as compared with aSLE. Moreover, cSLE versus aSLE was associated with a reduced risk of articular manifestations (OR: 0.63; 〈 i 〉 p 〈 /i 〉 = 0.001), pulmonary involvement (OR: 0.54; 〈 i 〉 p 〈 /i 〉 = 0.001), and pleuritis (OR: 0.61; 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). There were no significant differences between cSLE and aSLE for mortality risk (OR: 1.20; 〈 i 〉 p 〈 /i 〉 = 0.203). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 We found that certain clinical manifestations of SLE are different in cSLE and aSLE. Moreover, the mortality risk of cSLE and aSLE was not significantly different.
Type of Medium:
Online Resource
ISSN:
1018-2438
,
1423-0097
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
1482722-0
