In:
Annals of Nutrition and Metabolism, S. Karger AG, Vol. 78, No. 2 ( 2022), p. 61-72
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Vitamin D-binding protein (VDBP) is correlated with nonalcoholic fatty liver disease (NAFLD) through the biological functions of regulating plasma vitamin D (VD) level and the inflammatory process. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 This study aims to investigate the effects of VD level and 〈 i 〉 VDBP 〈 /i 〉 gene polymorphisms on the risk of NAFLD in a Chinese population. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Plasma 25-hydroxyvitamin D 〈 sub 〉 3 〈 /sub 〉 levels were measured and seven 〈 i 〉 VDBP 〈 /i 〉 candidate genetic variants (rs222020, rs2282679, rs4588, rs1155563, rs7041, rs16847024, rs3733359) were genotyped among participants in this case-control study. The control group was frequency-matched to the NAFLD case group by age and gender. Correlation analysis and multiple linear regressions were used to screen determinants of 25-hydroxyvitamin D 〈 sub 〉 3 〈 /sub 〉 levels. Multivariable unconditional logistic regression was performed to estimate odds ratio (OR) and 95% confidence interval (95% CI). The prediction capability of models containing independent factors was estimated by the area under the receiver operating characteristic curve and Hosmer-Lemeshow test. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Age, body mass index, and triacylglycerol were independent factors influencing VD levels. Participants with low VD levels had significantly higher prevalence of NAFLD compared to subjects with normal VD levels ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.001). A low VD level contributed to increased the risk of NAFLD, independent of metabolic factors known to affect VD levels (adjusted OR = 2.282, 95% CI = 1.422–3.661, 〈 i 〉 p 〈 /i 〉 = 0.001). Logistic regression analysis showed that individuals carrying rs7041-G allele had a significantly decreased the risk of NAFLD occurrence compared to T allele (additive model: adjusted OR = 0.814, 95% CI = 0.713–0.929, 〈 i 〉 p 〈 /i 〉 = 0.002; codominant model: adjusted OR = 0.623, 95% CI = 0.449–0.866, 〈 i 〉 p 〈 /i 〉 = 0.005), after adjusting for age, gender, and overweight. Stratification by multiple metabolic disorders did not alter this relationship. Moreover, we developed a simple model including age, gender, metabolic disorders, and 〈 i 〉 VDBP 〈 /i 〉 single nucleotide polymorphism (SNP) to assess NAFLD risk, an AUC of which being 0.817, significantly higher than the model not included 〈 i 〉 VDBP 〈 /i 〉 SNP, with Hosmer-Lemeshow test fitting well ( 〈 i 〉 p 〈 /i 〉 = 0.182). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Low plasma VD levels may increase susceptibility to NAFLD, while rs7041-G allele in 〈 i 〉 VDBP 〈 /i 〉 contributed to a decreased NAFLD risk among Chinese population. The 〈 i 〉 VDBP 〈 /i 〉 variant significantly improved the capability for NAFLD risk assessment, which could be used for early screening and management of NAFLD.
Type of Medium:
Online Resource
ISSN:
0250-6807
,
1421-9697
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
1481977-6
