In:
Oncology, S. Karger AG, Vol. 100, No. 11 ( 2022), p. 569-575
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 We investigated whether the expression of prospero homeobox protein-1 (PROX1) in gastric cancer (GC) could be a prognostic marker. We also focused on the relationship between PROX1 and LGR5 and Wnt/β-catenin activity in GC. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A total of 196 patients who underwent potentially curative surgery were collected and reviewed retrospectively. Immunohistochemistry was conducted and evaluated the expression PROX1, LGR5, Wnt3a, and β-catenin expression. And we evaluated the relationship between PROX1 expression and clinicopathological features. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The PROX1 low-expression group consisted of 105 patients (53.6%) and the high-expression group consisted of 91 patients (46.4%). For LGR5 expression, 76 patients (38.8%) were classified as low-expression, and 120 patients (61.2%) were classified as high-expression. The PROX1 low-expression group was significantly younger ( 〈 i 〉 p 〈 /i 〉 = 0.0095), had more intestinal type ( 〈 i 〉 p 〈 /i 〉 = 0.014), and had smaller tumor size ( 〈 i 〉 p 〈 /i 〉 = 0.013). The PROX1 high-expression group was significantly correlated with high LGR5 expression ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001) and high Wnt3a expression ( 〈 i 〉 p 〈 /i 〉 = 0.012). In addition, there were significantly more cases of postoperative recurrence in the PROX1 high-expression group ( 〈 i 〉 p 〈 /i 〉 = 0.013). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our findings demonstrate that PROX1 correlated with the cancer stemness markers LGR5 and Wnt3a signaling in GC and had a poor prognosis including postoperative recurrence.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2022
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6
