In:
Nephron, S. Karger AG, Vol. 147, No. 6 ( 2023), p. 317-328
Abstract:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Nonalcoholic fatty liver disease (NAFLD) is suggested as a risk factor for chronic kidney disease (CKD). The incidence of NAFLD is rising globally in parallel to the increasing incidences of obesity and type 2 diabetes. Diabetes remains the leading cause of CKD, but the co-existence of NAFLD, CKD, and type 2 diabetes is not well elucidated. Here, we evaluated the prevalence of NAFLD in patients with type 2 diabetes with and without CKD. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This was a cross-sectional study including 50 patients with type 2 diabetes and CKD stages 3–5 (no dialysis), and 50 patients with type 2 diabetes without CKD. Liver fat content was estimated by proton magnetic resonance spectroscopy and magnetic resonance imaging proton density fat fraction. NAFLD was defined as liver fat fraction ≥5.6% according to guidelines. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Mean age was 72 ± 4.9 years in patients with CKD and 65.9 ± 7.8 years in patients without CKD ( 〈 i 〉 p 〈 /i 〉 & #x3c; 0.0001). Three out of four participants were men. BMI was 28.6 ± 3.5 kg/m 〈 sup 〉 2 〈 /sup 〉 and 27 ± 4.0 kg/m 〈 sup 〉 2 〈 /sup 〉 in patients with and without CKD, respectively ( 〈 i 〉 p 〈 /i 〉 = 0.0087). NAFLD was identified in 22 (44%) patients with CKD and 19 (38%) patients without CKD ( 〈 i 〉 p 〈 /i 〉 = 0.6845). Median (IQR) liver fat fraction was 4.7% (3.0–8.5) and 4.1% (2.9–7.7) in patients with and without CKD, respectively (difference in geometric means 5.3%, 95% CI −23; 45, 〈 i 〉 p 〈 /i 〉 = 0.7463). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 These findings do not support any association between NAFLD and CKD (stages 3–5) in patients with type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
1660-8151
,
2235-3186
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
2810853-X
