In:
Psychotherapy and Psychosomatics, S. Karger AG, Vol. 92, No. 3 ( 2023), p. 180-192
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Different psychotherapeutic interventions for late-life depression (LLD) have been proposed, but their evaluation in large, multicenter trials is rare. 〈 b 〉 〈 i 〉 Objective: 〈 /i 〉 〈 /b 〉 The present study evaluated the efficacy of a specific cognitive behavioral therapy (CBT) for LLD (LLD-CBT) in comparison with a supportive unspecific intervention (SUI), both administered in a specialist psychiatric outpatient setting. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In this randomized, controlled, parallel group trial, we recruited participants (≥60 years) with moderate to severe depression at 7 trial sites in Germany. Participants were randomly assigned to the LLD-CBT or SUI group. The primary outcome was depression severity at the end of treatment measured by change on the Geriatric Depression Scale (GDS). Secondary outcomes included change in observer-rated depression, anxiety, sleep ratings, and quality of life throughout the treatment phase and at 6-month follow-up. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Between October 1, 2018, and November 11, 2020, we randomly assigned 251 patients to either LLD-CBT ( 〈 i 〉 n 〈 /i 〉 = 126) or SUI ( 〈 i 〉 n 〈 /i 〉 = 125), of whom 229 provided primary-outcome data. There was no significant between-group difference in the change in GDS scores at the end of treatment (estimated marginal mean difference: −1.01 [95% CI: −2.88 to 0.86]; 〈 i 〉 p 〈 /i 〉 = 0.287). Secondary analyses showed significant improvements in several outcomes after 8 weeks and at follow-up in both treatment arms. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Our data suggest that LLD-specific CBT and a supportive unspecific treatment both provide clinical benefit in patients with moderate to severe LLD without evidence for superiority of LLD-CBT.
Type of Medium:
Online Resource
ISSN:
0033-3190
,
1423-0348
Language:
English
Publisher:
S. Karger AG
Publication Date:
2023
detail.hit.zdb_id:
1472321-9
SSG:
5,2
SSG:
15,3
