In:
Respiration, S. Karger AG, Vol. 102, No. 8 ( 2023), p. 591-600
Kurzfassung:
〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 As fibrosing interstitial lung diseases (fILDs) are associated with high mortality, monitoring of disease activity under treatment is highly relevant. Krebs von den Lungen-6 (KL-6) is associated with the presence and severity of different fILDs, mainly in Asian patient populations. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 Our aim was to evaluate KL-6 as a predictive biomarker in fILDs in Caucasian patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Consecutive patients with fILDs were recruited prospectively and serum concentrations of KL-6 were measured at baseline (BL), after 6 and 12 months (6 Months, 12 Months). Clinical characteristics including pulmonary function tests were assessed at 6-monthly visits and correlated with KL-6 BL levels as well as with KL-6 level changes. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 A total of 47 fILD patients were included (mean age: 65 years, 68% male). KL-6 levels at BL were significantly higher in fILD patients than in healthy controls ( 〈 i 〉 n 〈 /i 〉 = 44, mean age: 45, 23% male) (ILD: 1,757 ± 1960 U/mL vs. control: 265 ± 107 U/mL, 〈 i 〉 p 〈 /i 〉 & lt; 0.0001). However, no differences were noted between ILD subgroups. KL-6 decreased significantly under therapy (6M∆BL-KL6: −486 ± 1,505 mean U/mL, 〈 i 〉 p 〈 /i 〉 = 0.032; 12M∆BL-KL6: −547 ± 1,782 mean U/mL, 〈 i 〉 p 〈 /i 〉 = 0.041) and KL-6 level changes were negatively correlated with changes in pulmonary function parameters (forced vital capacity [FVC]: 〈 i 〉 r 〈 /i 〉 = −0.562, 〈 i 〉 p 〈 /i 〉 & lt; 0.0001; DLCO 〈 sub 〉 SB 〈 /sub 〉 : 〈 i 〉 r 〈 /i 〉 = −0.405, 〈 i 〉 p 〈 /i 〉 = 0.013). While neither absolute KL-6 levels at BL nor KL-6 level changes were associated with ILD progression (FVC decline ≥10%, DLCO 〈 sub 〉 SB 〈 /sub 〉 decline ≥15% or death), patients with a stable FVC showed significantly decreasing KL-6 levels ( 〈 i 〉 p 〈 /i 〉 = 0.022). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 A decline of KL-6 under therapy correlated with a clinically relevant stabilization of lung function. Thus, KL-6 might serve as a predictive biomarker, which however must be determined by larger prospective cohorts.
Materialart:
Online-Ressource
ISSN:
0025-7931
,
1423-0356
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
2023
ZDB Id:
1464419-8
