In:
Oncology, S. Karger AG
Abstract:
〈 b 〉 〈 i 〉 Introduction: 〈 /i 〉 〈 /b 〉 Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide. Lack of biomarkers for follow-up after treatment is a clinical challenge. DNA methylation has been proposed to be a potential biomarker in HCC. However, there is still a lack of evidence of its clinical use. This study aimed to evaluate the value of using plasma Adenomatous Polyposis Coli promoter methylation level (APC-MET) as a potential biomarker in HCC treatment. 〈 b 〉 〈 i 〉 Method: 〈 /i 〉 〈 /b 〉 A total of 96 patients with HCC at BCLC stage B who underwent local tumor ablation treatment were prospectively included in this study. APC-MET was examined in the plasma of each patient before and 1 month after treatment. The prediction value of APC-MET for survival outcome and disease status after treatment was analyzed and adjusted with alpha-fetoprotein and protein induced by vitamin K absence-II using Cox regression analysis. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Univariate Cox regression analysis showed preoperative APC-MET & gt;0 (HR, 2.9, 95% CI: 1.05–8.05, 〈 i 〉 p 〈 /i 〉 = 0.041) and postoperative APC-MET & gt;0 (HR, 3.47, 95% CI: 1.16–10.4, 〈 i 〉 p 〈 /i 〉 = 0.026) were both predictors of death, and preoperative APC-MET & gt;0 was a predictor of disease progression after treatment (HR, 2.04, 95% CI: 1.21–3.44, 〈 i 〉 p 〈 /i 〉 = 0.007). In multivariate models, preoperative APC-MET & gt;0 was a significant predictor of disease progression after adjusting with the other two traditional biomarkers (HR, 1.82, 95% CI: 1.05–3.17, 〈 i 〉 p 〈 /i 〉 = 0.034). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Hypermethylation of APC promoter appears to be a potential biomarker that could predict patient survival and disease progression outcomes in patients with intermediate-stage HCC after local ablation treatment.
Type of Medium:
Online Resource
ISSN:
0030-2414
,
1423-0232
Language:
English
Publisher:
S. Karger AG
Publication Date:
2024
detail.hit.zdb_id:
1483096-6
detail.hit.zdb_id:
250101-6
