KOBV-Portal

Treffer pro Seite

Treffer 1 - 1 | 1 Treffer

Alles auswählen Exportieren

Online-Ressource

Platelet Inhibition by Insulin Is Absent in Type 2 Diabetes Mellitus

Ferreira, Irlando Andrade ; Mocking, Astrid I.M. ; Feijge, Marion A.H. ; [weitere]

Ovid Technologies (Wolters Kluwer Health) ; 2006

In: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 26, No. 2 ( 2006-02), p. 417-422

zur Merkliste hinzufügen auf der Merkliste

Details

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 26, No. 2 ( 2006-02), p. 417-422

Kurzfassung: Insulin inhibits Ca 2+ mobilization in platelets by interfering with P2y 12 -mediated cAMP suppression. Here we show that DM2 platelets have lost responsiveness to insulin and also show increased P2y 12 signaling. This might explain the increased platelet deposition and procoagulant activity under flow of DM2 platelets on contact with collagen.

Materialart: Online-Ressource

ISSN: 1079-5642 , 1524-4636

URL: Article

DOI: 10.1161/01.ATV.0000199519.37089.a0

Sprache: Englisch

Verlag: Ovid Technologies (Wolters Kluwer Health)

Publikationsdatum: 2006

ZDB Id: 1494427-3