In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 108, No. 18 ( 2003-11-04), p. 2198-2200
Abstract:
Background— Thermodilution coronary flow reserve (CFR thermo ) is a new technique for invasively measuring coronary flow reserve (CFR) with a coronary pressure wire and is based on the ability of the pressure transducer to also measure temperature changes. Whether CFR thermo correlates well enough with absolute flow-derived CFR (CFR flow ) to replace Doppler wire–derived CFR (CFR Doppler ) remains unclear. Methods and Results— In an open-chest pig model, CFR thermo was measured in the left anterior descending (LAD) artery and compared with CFR Doppler and CFR flow , measured with an external flow probe placed around the LAD. In 9 pigs, CFR was measured simultaneously by all 3 means in the normal LAD and after creation of an epicardial LAD stenosis. To determine the added effect of microvascular disease, measurements of flow reserve were also performed after disruption of the coronary microcirculation with embolized microspheres. Intracoronary papaverine (20 mg) was used to induce hyperemia. In a total of 61 paired measurements, CFR thermo correlated strongly with the reference standard CFR flow ( r =0.85, P 〈 0.001). CFR Doppler correlated less well with CFR flow ( r =0.72, P 〈 0.001). Bland-Altman analysis showed a closer agreement between CFR thermo and CFR flow . Conclusion— CFR thermo correlates better with CFR flow than does CFR Doppler .
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/01.CIR.0000099521.31396.9D
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2003
detail.hit.zdb_id:
1466401-X
