In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 7 ( 2007-07), p. 1610-1617
Kurzfassung:
Apolipoprotein E (apoE) exerts antiatherogenic effects, but precise mechanisms remain unclear. The present study demonstrates that apoE suppress IL-1β-induced inflammatory activation of vascular smooth muscle cells by targeting IL receptor-associated kinase-1 (IRAK-1) and transcription factors NF-κB and AP-1 in a process dependent on protein kinase A (PKA).
Materialart:
Online-Ressource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/ATVBAHA.106.129957
Sprache:
Englisch
Verlag:
Ovid Technologies (Wolters Kluwer Health)
Publikationsdatum:
2007
ZDB Id:
1494427-3