In:
Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 27, No. 8 ( 2007-08), p. 1729-1735
Abstract:
Tolerance to nitroglycerin is likely attributable to an increased production of reactive oxygen species and an inhibition of its bioactivating enzyme. Pentaerythrityl tetranitrate (PETN) therapy is devoid of tolerance, potentially because of HO-1 induction. Inhibition of HO-1 expression induced “tolerance” to PETN, whereas HO-1 induction prevented tolerance in nitroglycerin-treated rats.
Type of Medium:
Online Resource
ISSN:
1079-5642
,
1524-4636
DOI:
10.1161/ATVBAHA.107.143909
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2007
detail.hit.zdb_id:
1494427-3
