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Estrogen Decreases Atherosclerosis in Part by Reducing Hepatic Acyl-CoA:Cholesterol Acyltransferase 2 (ACAT2) in Monkeys

Kavanagh, Kylie ; Davis, Matthew A. ; Zhang, Li ; [weitere]

Ovid Technologies (Wolters Kluwer Health) ; 2009

In: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 29, No. 10 ( 2009-10), p. 1471-1477

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In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 10 ( 2009-10), p. 1471-1477

Kurzfassung: Estrogen inhibits atherogenesis. We demonstrate in ovariectorized monkeys that estrogen therapy led to lower hepatic and circulating lipoprotein cholesterol, and lower ACAT2 protein and associated activity levels as compared to controls. Hepatic ACAT2 activity was highly correlated with, and was an independent predictor of, coronary artery atherosclerosis extent.

Materialart: Online-Ressource

ISSN: 1079-5642 , 1524-4636

URL: Article

DOI: 10.1161/ATVBAHA.109.191825

Sprache: Englisch

Verlag: Ovid Technologies (Wolters Kluwer Health)

Publikationsdatum: 2009

ZDB Id: 1494427-3