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The Phosphorylation Motif at Serine 225 Governs the Localization and Function of Sphingosine Kinase 1 in Resistance Arteries

Lidington, Darcy ; Peter, Bernhard Friedrich ; Meissner, Anja ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2009

In: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 29, No. 11 ( 2009-11), p. 1916-1922

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In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 29, No. 11 ( 2009-11), p. 1916-1922

Abstract: We demonstrate in hamster resistance arteries that the serine 225 phosphorylation site on sphingosine kinase 1 (Sk1) is a molecular switch for its regulatory function in smooth muscle cells. It is critical for pressure-dependent Sk1 activation/translocation and cannot be bypassed by an artificial membrane anchor.

Type of Medium: Online Resource

ISSN: 1079-5642 , 1524-4636

URL: Article

DOI: 10.1161/ATVBAHA.109.194803

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2009

detail.hit.zdb_id: 1494427-3